Abstract Purpose. To design new antithyroid agents with less side effects, the electrotopological-state (E-state) indexes of thiourylene moiety (S N&S) was utilized as a guideline to develop five acyclic thio-urylene-type compounds with reduced antioxidant property. Methods. These agents were synthesized and screened for antithyroid activity in rats using 125 I-thiocyanate discharge technique. In addition, chemiluminescence studies ...
