Synthesis and pharmacological properties of 2-substituted-3-aryl-3-hydroxyquinuclidines

VA Bondarenko, TK Trubitsyna, OS Anisimova…

Index: Bondarenko, V. A.; Trubitsyna, T. K.; Anisimova, O. S.; Mikhlina, E. E.; Mashkovskii, M. D.; Yakhontov, L. N. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 3 p. 207 - 211 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 3 p. 307 - 311

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Abstract

Results. Examination showed all the compounds to display adrenomimetic activity. In narcotized cats at a dose of 1-5 mg/kg, compounds (IIa-e)(hydrochlorides and methiodides) gave rise to a brief reduction in arterial pressure, did not shorten the third eyelid, and in concentrations of i'i0-sg/ml had slight vasoconstrictor effect (10-15%). Unlike the 8-stimulator isoproterenol, which is active at a dose of 0.5 mg/kg, these compounds did not accelerate ...