4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: Synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation

S Yadav, P Kumar, E De Clercq, J Balzarini…

Index: Yadav, Snehlata; Kumar, Pradeep; De Clercq, Erik; Balzarini, Jan; Pannecouque, Christophe; Dewan, Sharwan Kumar; Narasimhan, Balasubramanian European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5985 - 5997

Full Text: HTML

Citation Number: 21

Abstract

A series of 4-[1-(substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzene sulphonic acids (1-20) was synthesized and evaluated, in vitro, for their antimicrobial activity and the results indicated that compounds 4-[1-(4-Nitrobenzoyl)-1H-benzoimidazol-2-yl]- benzenesulfonic acid (9) and 4-(1-octadec-9-enoyl-1H-benzoimidazol-2-yl)- benzenesulfonic acid (18) were found to be the most active ones. QSAR investigations ...