Abstract Evidence is presented that melicopine (1, 2-dimethoxy-10-methyl-3, 4-methyl- enedioxyacridone) reacts with bromine in methanol to yield a compound which is formulated as an aryl dihypobromite. Demethylation of the 1-methoxyl group occurs, followed by addition of bromine and methanol to the oxygenated ring. The reactions of this hypobromite are discussed, and several degradation products synthesized.
![1,3-Dioxolo[4,5-c]acridin-6(11H)-one,4,5-dimethoxy-11-methyl- Structure](https://image.chemsrc.com/caspic/166/568-01-4.png)
![5-hydroxy-4,11b-dimethoxy-11-methyl-11,11b-dihydro-[1,3]dioxolo[4,5-c]acridin-6(3aH)-one Structure](https://image.chemsrc.com/caspic/411/14382-75-3.png)