Bioorganic & medicinal chemistry letters

Synthesis, characterization and antiamoebic activity of 1-(thiazolo [4, 5-b] quinoxaline-2-yl)-3-phenyl-2-pyrazoline derivatives

M Abid, A Azam

Index: Abid, Mohammad; Azam, Amir Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 10 p. 2812 - 2816

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Citation Number: 95

Abstract

A new series of 1-N-thiocarboxamide-3-phenyl-2-pyrazolines 1–6 was synthesized by cyclization of different Mannich bases with unsubstituted thiosemicarbazide. The reaction of cyclized pyrazoline derivatives 1–6 with 2, 3-dichloroquinoxaline afforded the title compounds 7–12. The structures of the new compounds were confirmed by elemental analyses as well as 1H, 13C NMR, IR and electronic spectral data. The HM1: IMSS strain ...