Tetrahedron

Mixed catechol-hydroxamate and catechol-(o-hydroxy) phenacyl siderophores: synthesis and uptake studies with receptor-deficient Escherichia coli mutants

R Schobert, A Stangl, K Hannemann

Index: Schobert, Rainer; Stangl, Andreas; Hannemann, Kerstin Tetrahedron, 2008 , vol. 64, # 8 p. 1711 - 1720

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Citation Number: 7

Abstract

Biscatechol-hydroxamate and catechol-bishydroxamate chelators of similar architecture were synthesized by a small set of acylation reactions, Michael additions, and domino Wittig alkenations and they were tested for siderophoric activity in various receptor-deficient mutants of Escherichia coli under iron starvation. Growth promotion occurred only in mutants featuring catecholate recognizing receptors. Simplified mimics of the natural siderophores ...