A general method for making peptide therapeutics resistant to serine protease degradation: application to dipeptidyl peptidase IV substrates

…, P Zhao, I Woznica, JH Lai, M Beinborn…

Index: Heard, Kathryn R.; Wu, Wengen; Li, Youhua; Zhao, Peng; Woznica, Iwona; Lai, Jack H.; Beinborn, Martin; Sanford, David G.; Dimare, Matthew T.; Chiluwal, Amrita K.; Peters, Diane E.; Whicher, Danielle; Sudmeier, James L.; Bachovchin, William W. Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8339 - 8351

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Citation Number: 9

Abstract

Bioactive peptides have evolved to optimally fulfill specific biological functions, a fact which has long attracted attention for their use as therapeutic agents. While there have been some recent commercial successes fostered in part by advances in large-scale peptide ...