Directed lithiations are important reactions for the functionalization of arenes and heterocycles.[1] In contrast, directed magnesiation with magnesium bases has been used much less often.[2] The pioneering work of Eaton et al.[3] demonstrated the potential of this approach using magnesium bis (2, 2, 6, 6-tetramethylpiperamide),(tmp) 2Mg. However, the limited solubility of such bases in common organic solvents as well as the requirement for ...
