To gain insight into the spatial nature of the androstenedione (AD) binding (active) site of aromatase in relation to the catalytic function of the enzyme, we synthesized 2, 2-dimethylAD (4), 2β-and 2α-methylADs (5 and 6), 19-oxygenated derivatives of compounds 4 and 6, and 2-methyleneAD (17), and we then tested their inhibitory activity as well as their aromatase reaction (aromatization for 2-methyl and 2-methylene analogs or 19-oxygenation for 2, 2- ...
![(8S,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-2-methylidene-6,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-one Structure](https://image.chemsrc.com/caspic/390/2137-38-4.png)
