The general reaction of hydrochlorides of aromatic amines with sodium thiocyanoacetate in water at room temperature, to give a-carbamylmercaptoacetyl derivatives of the amine2: Ar- NH2+ COOH-CH2-SCN+ 4r-NH-CO-CH2-S-CO-NH2 (I) has been extended to 6-and 8- aminoquinoline. From the latter amine the sparingly water-soluble thiocyanoacetate was obtained first; this salt isomerized to the amide [I,, 4r= 8-C9H7N] with much greater ease ...
