Molecules

A facile synthesis of functionalized dispirooxindole derivatives via a three-component 1, 3-dipolar cycloaddition reaction

J He, G Ouyang, Z Yuan, R Tong, J Shi, L Ouyang

Index: He, Jun; Ouyang, Guang; Yuan, Zhixiang; Tong, Rongsheng; Shi, Jianyou; Ouyang, Liang Molecules, 2013 , vol. 18, # 5 p. 5142 - 5154

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Citation Number: 8

Abstract

Abstract: An efficient synthesis of novel dispirooxindoles has been achieved through three- component 1, 3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5- benzylideneimidazolidine-2, 4-dione. The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational ...