Scalable enantioseparation of amino acid derivatives using continuous liquid− liquid extraction in a cascade of centrifugal contactor separators

…, JGM Winkelman, JG de Vries, HJ Heeres

Index: Schuur, Boelo; Hallett, Andrew J.; Winkelman, Jozef G.M.; De Vries, Johannes G.; Heeres, Hero J. Organic Process Research and Development, 2009 , vol. 13, # 5 p. 911 - 914

Full Text: HTML

Citation Number: 54

Abstract

Using a cascade of six centrifugal contactor separators in a countercurrent liquid− liquid extraction mode allowed the separation of one of the enantiomers of 3, 5-dinitrobenzoyl- leucine in 55% yield and 98% ee using a catalytic amount of a chiral host compound based on a cinchona alkaloid. This method allows the preparation of kilograms of enantiopure material in table-top-sized equipment that can be operated in a fume cupboard. The ...