Cell reports

Identifying family-member-specific targets of mono-ARTDs by using a chemical genetics approach

I Carter-O'Connell, H Jin, RK Morgan, R Zaja, LL David…

Index: Carter-O'Connell, Ian; Jin, Haihong; Morgan, Rory K.; David, Larry L.; Cohen, Michael S. Journal of the American Chemical Society, 2014 , vol. 136, # 14 p. 5201 - 5204

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Citation Number: 5

Abstract

Summary ADP-ribosyltransferases (ARTD1–16) have emerged as major downstream effectors of NAD+ signaling in the cell. Most ARTDs (ARTD7 and 8, 10–12, and 14–17) catalyze the transfer of a single unit of ADP-ribose from NAD+ to target proteins, a process known as mono-ADP-ribosylation (MARylation). Progress in understanding the cellular functions of MARylation has been limited by the inability to identify the direct targets for ...