Muscarinic receptor binding and activation of second messengers by substituted N-methyl-N-[4-(1-azacycloalkyl)-2-butynyl] acetamides

…, U Kammula, J Zimmet, KA Jacobson

Index: Bradbury, Barton J.; Baumgold, Jesse; Paek, Robert; Kammula, Udai; Zimmet, Jeff; Jacobson, Kenneth A. Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1073 - 1079

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Citation Number: 18

Abstract

A series of substituted azacycloalkyl analogues of the muscarinic agonist UH 5 (N-methyl-N- [4-(l-pyrolidinyl)-2-butynyl] acetamide, la) were synthesized and evaluated pharmacologically. These compounds were developed as intermediates for further derivatization leading to functionalized congeners of la. The compounds were synthesized by using a Mannich-type condensation of N-acetyl-N-methylpropargylamine to various ...