Antimitotic activities of 2-phenylindole-3-carbaldehydes in human breast cancer cells

…, S Vogel, R Liebl, R Gastpar, D Gross, T Nishino…

Index: Kaufmann, Doris; Pojarova, Michaela; Vogel, Susanne; Liebl, Renate; Gastpar, Robert; Gross, Dietmar; Nishino, Tsuyuki; Pfaller, Tobias; von Angerer, Erwin Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 15 p. 5122 - 5136

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Citation Number: 55

Abstract

Small molecules such as indoles are attractive as inhibitors of tubulin polymerization. Thus a number of 2-phenylindole-3-carbaldehydes with lipophilic substituents in both aromatic rings was synthesized and evaluated for antitumor activity in MDA-MB 231 and MCF-7 breast cancer cells. Some 5-alkylindole derivatives with a 4-methoxy group in the 2-phenyl ring strongly inhibit the growth of breast cancer cells with IC50 values of 5–20nM. Their ...