Isoxazoles with antipicornavirus activity

GD Diana, MA McKinlay, CJ Brisson…

Index: Diana; McKinlay; Brisson; Zalay; Miralles; Salvador Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 748 - 752

Full Text: HTML

Citation Number: 50

Abstract

The synthesis and evaluation of a series of 3, 5-disubstituted isoxazoles as antipicornavirus agents have led to the discovery of several compounds effective in vitro against rhinovirus type 2 and poliovirus type 2. Compound 32 was found more effective than 4', 6- dichloroflavan against both viruses and was evaluated orally in mice infected intracerebrally with polio-2. At 31 mg/kg bid, compound 32 showed a 53% survival rate as compared to ...