2, 2, 2-Trichloromethylcarbinols are 1 are valuable synthetic intermediates with a multitude of uses. A scalable procedure for the synthesis of TMS-protected-2, 2, 2- trichloromethylcarbinols and 2, 2, 2-trichloromethylcarbinols 1 was developed that employs the in situ generation and reaction of trimethyl (trichloromethyl) silane (CCl3-TMS). The procedure avoids the exposure of the carbonyl compounds to the strongly basic ...
