A method for parallel solid-phase synthesis of iodinated analogues of the CB1 receptor inverse agonist Rimonabant

AC Spivey, CC Tseng, TC Jones, AD Kohler…

Index: Turner, David J.; Anemian, Remi; MacKie, Philip R.; Cupertino, Domenico C.; Yeates, Stephen G.; Turner, Michael L.; Spivey, Alan C. Organic and Biomolecular Chemistry, 2007 , vol. 5, # 11 p. 1752 - 1763

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Citation Number: 11

Abstract

A method for the parallel solid-phase synthesis (SPS) of iodinated analogues of Sanofi- Aventis' type 1 cannabinoid (CB1) receptor inverse agonist rimonabant (acomplia) has been developed. The method allows the synthesis of a range of C3 amide/hydrazide derivatives