Helvetica chimica acta

Synthesis and Spectroscopic Characterization of 4??Chlorophenyl Isocyanate (= 1??chloro??4??isocyanatobenzene) Adducts with Amino Acids as Potential Dosimeters …

M Möller, D Henschler, G Sabbioni

Index: Moeller, Marianne; Henschler, Dietrich; Sabbioni, Gabriele Helvetica Chimica Acta, 1998 , vol. 81, # 7 p. 1254 - 1263

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Citation Number: 6

Abstract

Abstract Blood-protein adducts are used as dosimeter for modifications of macromolecules in the target organs where the disease develops. The functional groups of cysteine, tyrosine, serine, lysine, tryptophan, histidine and N-terminal amino acids are potential reaction sites for isocyanates. Especially the N-terminal amino acids, valine and aspartic acid of hemoglobin and albumin, respectively, are reactive towards electrophilic xenobiotics. To ...