Studies on quinones. Part 44: Novel angucyclinone N-heterocyclic analogues endowed with antitumoral activity

JA Valderrama, P Colonelli, D Vásquez…

Index: Valderrama, Jaime A.; Colonelli, Pamela; Vasquez, David; Gonzalez, M. Florencia; Rodriguez, Jaime A.; Theoduloz, Cristina Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 24 p. 10172 - 10181

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Citation Number: 38

Abstract

In the search for new potentially anticancer drugs, series of angucyclinone aza-analogues containing pyridine and pyridopyridazine rings have been designed and synthesized by a highly efficient sequence involving a one-pot step for the synthesis of tricyclic quinone intermediate and highly regiocontrolled cycloaddition reactions with polarized 1, 3-dienes. The new N-heterocyclic angular quinones were evaluated in vitro on normal human ...