Synthesis of 11-hydroxyl O-methylsterigmatocystin and the role of a cytochrome P-450 in the final step of aflatoxin biosynthesis

…, LK Casillas, CA Townsend

Index: Udwary, Daniel W.; Casillas, Linda K.; Townsend, Craig A. Journal of the American Chemical Society, 2002 , vol. 124, # 19 p. 5294 - 5303

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Citation Number: 51

Abstract

The major skeletal rearrangements (anthraquinone→ xanthone→ coumarin) that occur in the complex biosynthesis of aflatoxin B1 are mediated by cytochromes P-450. Previous experiments have suggested that two successive monooxygenase reactions are required to convert the xanthone O-methylsterigmatocystin (OMST) to aflatoxin, a process we demonstrate is mediated by a single P-450, OrdA, in Aspergillus parasiticus in accord with ...