Wrenchnolol derivative optimized for gene activation in cells

D Jung, H Shimogawa, Y Kwon, Q Mao…

Index: Jung, Dongju; Shimogawa, Hiroki; Kwon, Youngjoo; Mao, Qian; Sato, Shin-ichi; et al. Journal of the American Chemical Society, 2009 , vol. 131, p. 4774 - 4782

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Citation Number: 17

Abstract

Naturally occurring transcription factors usually have two independent domains, a DNA- binding domain and an activation domain. In designing a synthetic small molecule that mimics a transcription factor, each of the two domains needs to be replaced by small- molecule counterparts. Results of the present study show that derivatives of wrenchnolol, a synthetic molecule that interacts with Sur-2 coactivator, serve as activation modules and ...