Synthesis of a 3-(α-Styryl) benzo [b]-thiophene Library via Bromocyclization of Alkynes and Palladium-Catalyzed Tosylhydrazones Cross-Couplings: Evaluation as …

…, J Bignon, J Dubois, JD Brion, M Alami…

Index: Lawson, Marie; Hamze, Abdallah; Peyrat, Jean-Francois; Bignon, Jerome; Dubois, Joelle; Brion, Jean-Daniel; Alami, Mouad Organic and Biomolecular Chemistry, 2013 , vol. 11, # 22 p. 3664 - 3673

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Citation Number: 8

Abstract

A library of functionalized 3-(α-styryl)-benzo [b] thiophenes, endowed with a high level of molecular diversity, was efficiently synthesized by applying a synthetic sequence that allowed introduction of various substituents on aromatic A, B, and C-rings. The strategy developed involves the synthesis of 3-bromobenzo [b] thiophene derivatives through a bromocyclization step of methylthio-containing alkynes using N-methylpyrrolidin-2-one ...