Several years ago, Rapoport studied the Cr03 oxidation in dilute H2S04 of codeine and some of its congener^.^ In each case the corresponding loa-hydroxy analogues were obtained accompanied by large amounts of recovered starting material. Very low yields of the corresponding keto compounds were realized. Using similar conditions with oxycodone as the substrate, we isolated the loa-OH analogue 5, which was formed in 4.2% yield, and ...
![(4S,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a-hydroxy-9-methoxy-1,2,4,5,6,7a-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7,13-dione Structure](https://image.chemsrc.com/caspic/139/96445-13-5.png)
