Synlett

Synthesis of Novel Annulated Hymenialdisine Analogues via Palladium-Catalyzed Cross-Coupling Reactions with Aryl Boronic Acids

N Mangu, A Spannenberg, M Beller, MK Tse

Index: Mangu, Naveenkumar; Spannenberg, Anke; Beller, Matthias; Tse, Man-Kin Synlett, 2010 , # 2 p. 211 - 214

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Citation Number: 4

Abstract

Nevertheless, with the key building block 8 in hand, we envisioned the synthesis of novel hymenialdisine analogues following standard Suzuki coupling protocols. [¹6] Treatment of 8 with 4-methoxyphenyl boronic acid (1.1 equiv) in the presence of Pd(PPh 3 ) 4 (1 mol%) and aqueous sodium carbonate (2 M) as base in a mixture of toluene and ethanol (1:1) at 70 ˚C for 12-16 h, gave the desired product along with minor amounts of the deprotected compound 9a (R = ...