A Novel One??Pot, Two??Step Synthesis of Polycyclic Indoles via Tandem Intramolecular Hydroamidation/Palladium??Catalyzed Annulation

…, Y Zhang, G Li, F Roschangar, V Farina…

Index: Liu, Jianxiu; Zhang, Yongda; Li, Guisheng; Roschangar, Frank; Farina, Vittorio; Senanayake, Chris H.; Lu, Bruce Z. Advanced Synthesis and Catalysis, 2010 , vol. 352, # 14-15 p. 2667 - 2671

Full Text: HTML

Citation Number: 18

Abstract

A robust one-pot process has been developed for the synthesis of a variety of polycyclic indole skeletons via a consecutive sequence of hydroamidation and palladium-catalyzed annulation, from inexpensive 2-chloroanilines bearing tethered acetylenes. ... Recently, we have disclosed a novel regioselective Pd-catalyzed indolization from 2-chloroanilides tethered to internal alkynes,4 based on the previous protocol developed in this group.5 This unusual ...