Synthèse de la d, l-(acetoxy-2 octadecylthio-1) propyl-3 phosphorylcholine ou thia-PAF

B Garrigues, G Bertrand, D Frehel…

Index: Garrigues, Bernard; Bertrand, Guy; Frehel, Daniel; Maffrand, Jean-Pierre Phosphorus and Sulfur and the Related Elements, 1984 , vol. 21, p. 171 - 176

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Citation Number: 6

Abstract

Abstract d, l-thia-PAF [d, l-(2-acetoxy-l-octadecylthio)-3-propylphosphorylcholine] 2 was synthesised using a selective method of protection (ClSiMe2t-Bu) and deprotection (BF3- Et2O) of the primary alcohol function. This method could be used with advantage in the synthesis of other phospholipids as it avoids an isomerisation by internal trans-acylation at the deprotection step. Nous avons synthétisé le d, l-thia-PAF [d, l-(acétoxy-2 octadécylthio- ...