Green chemistry: A facile synthesis of polyfunctionally substituted thieno [3, 4-c] pyridinones and thieno [3, 4-d] pyridazinones under neat reaction conditions

KM Al-Zaydi, RM Borik, RA Mekheimer…

Index: Al-Zaydi, Khadijah M.; Borik, Rita M.; Mekheimer, Ramadan A.; Elnagdi, Mohamed H. Ultrasonics Sonochemistry, 2010 , vol. 17, # 5 p. 909 - 915

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Citation Number: 10

Abstract

A facile, solvent free, ecofriendly approach for the synthesis of pyridine-2, 6-diones 4a–d, pyridazinone derivatives 8a–c and thienoazines 6 and 9 is herein described employing neat reaction conditions under both microwave and ultrasound irradiations. This solventless methodology is environmentally benign as it completely eliminates the use of solvent from the reaction procedure.