Novel 1, 2-dithiins: synthesis, molecular modeling studies, and antifungal activity

…, JM Dener, LG Dubenko, RE Gerber…

Index: Bierer, Donald E.; Dener, Jeffrey M.; Dubenko, Larisa G.; Gerber, R. Eric; Litvak, Joane; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 14 p. 2628 - 2648

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Citation Number: 58

Abstract

1, 2-Dithiins (1, 2-dithiacyclohexadienes) are six-membered heterocycles characterized by a disulfide linkage in the place of two contiguous CH groups of benzene. Photosensitive and deeply colored, 1, 2-dithiins have long been the subject of intense theoretical interest primarily due to their 8n electron antiar~ maticl-~ ring system. Naturally occurring 1, 2- dithiins (thiarubrines) were first identified in the mid-1960~~ 3~ in plants of the family ...