Design and synthesis of novel polycycles based on the 3H??pyrrolo/6, 7??dihydropyrido [1, 2??a] indole scaffold as templates for pharmaceutical development

…, N Pala, V Sanna, R Dallocchio, A Dessì…

Index: Derudas, Marco; Pala, Nicolino; Sanna, Vanna; Dallocchio, Roberto; Dessi, Alessandro; Roggio, Anna Maria; Sechi, Mario Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 5 p. 1161 - 1168

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Abstract

Abstract In the course of our work aimed at developing novel heterocycles of pharmaceutical interest, we designed and synthesized several polycyclic templates as potential substrates to be used in drug design. We obtained a set of condensed ring systems as versatile structural platforms to generate potential DNA-interactive agents and/or reversible inhibitors of enzymes such as topoisomerases, poly (ADP-ribose) polymerase-1 (PARP-1), ...