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Synthesis of a boronated amino acid as a potential neutron therapy agent: 1-amino-3-[(dihydroxyboryl) ethyl] cyclobutanecarboxylic acid

GW Kabalka, ML Yao, A Navarane

Index: Kabalka, George W.; Yao, Min-Liang; Navarane, Abhijit Tetrahedron Letters, 2005 , vol. 46, # 29 p. 4915 - 4917

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Citation Number: 6

Abstract

A novel boronated aminocyclobutanecarboxylic acid was synthesized in 10 steps for potential use in neutron capture therapy. The molecule was modeled after the unnatural amino acid 1-aminocyclobutanecarboxylic acid, which has shown high uptake in brain tumors.