Synthesis

Aqueous-phase Suzuki-Miyaura cross-coupling reactions of free halopurine bases

P Čapek, M Vrabel, Z Hasník, R Pohl, M Hocek

Index: Capek, Petr; Vrabel, Milan; Hasnik, Zbynek; Pohl, Radek; Hocek, Michal Synthesis, 2006 , # 20 p. 3515 - 3526

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Citation Number: 21

Abstract

Abstract The Suzuki-Miyaura reaction of 9-unsubstituted 2-, 6-, and 8-halopurine bases with diverse aryl-and alkenylboronic acids in water-acetonitrile mixtures under microwave irradiation was used for the single-step synthesis of arylpurines. In most cases the product crystallized directly from the reaction mixture in high yields and good purity. The scope and limitations of these reactions were studied.