A PRACTICAL LARGE-SCALE PREPARATION OF 5'-BROMOSPIRO (CYCLOHEXANE-1, 3-[3H] INDOL)-2'(1'H)-ONE

BK Wilk, A Rubezhov, JL Helorn…

Index: Organic Preparations and Procedures International, , vol. 37, # 3 p. 283 - 285

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Abstract

... The dark red, organic layer was washed with brine (250 mL) and transferred to a 5-L distillation ... dibromo- and 1,5-diiodopentane were tried with no apparent improvement in the yield and the purification procedure. ... We found this method impractical for a large-scale preparation. ...

Design, synthesis, and SAR of new pyrrole-oxindole progester...

[Fensome, Andrew; Adams, William R.; Adams, Andrea L.; Berrodin, Tom J.; Cohen, Jeff; Huselton, Christine; Illenberger, Arthur; Kern, Jeffrey C.; Hudak, Valerie A.; Marella, Michael A.; Melenski, Edward G.; McComas, Casey C.; Mugford, Cheryl A.; Slayden, Ov D.; Yudt, Matthew; Zhang, Zhiming; Zhang, Puwen; Zhu, Yuan; Winneker, Richard C.; Wrobel, Jay E. Journal of Medicinal Chemistry, 2008 , vol. 51, # 6 p. 1861 - 1873]

A PRACTICAL LARGE-SCALE PREPARATION OF 5'-BROMOSPIRO (CYCLOH...

[Wilk, Bogdan K.; Rubezhov, Arkadiy; Helom, Jean L.; Routel, Lisa R.; Potoski, John R. Organic Preparations and Procedures International, 2005 , vol. 37, # 3 p. 283 - 285]