Abstract Twelve isoquinoline alkaloids including two new nitro-containing tetrahydroprotoberberines,(−)-2, 9-dihydroxyl-3, 11-dimethoxy-1, 10- dinitrotetrahydroprotoberberine (1) and (+)-4-nitroisoapocavidine (2), were isolated from the whole plant of Corydalis saxicola Bunting. The structures of the new compounds were established by spectroscopic analysis and chemical evidence. The inhibitory activity of ...