Abstract In connection with the tuberculostatic and pharmacological properties of 4-hydroxy- 6-amino-isophthalic acid (4-hydroxy-6-aminobenzene-1, 3-dicarboxylic acid) a synthesis with 4, 6-dinitro-m-xylene (1, 3-dimethyl-4, 6-dinitrobenzene) as starting material is described. Other alternate routes are discussed.