2-(3-amino-2-hydroxypropoxy) phenoxymethyloxazoles as potential β-and α-adrenoblocking agents

…, MD Mashkovskii, SD Yuzhakov, VN Ermakova

Index: Sokolov, S. D.; Vinogradova, S. M.; Berg, M. V.; Mashkovskii, M. D.; Yuzhakov, S. D.; Ermakova, V. N. Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 1 p. 30 - 36 Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 1 p. 48 - 54

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Abstract

Method B. A mixture of ll. O g (0. i mole) of pyrocatechol, 16.7 g (0.075 mole) of 3-methyl-4- chloro-5-bromomethylisoxazole and 13.8 g of anhydrous potassium carbonate was boiled with vigorous stirring for I0 h. The acetone was removed in vacuo, and the residue was treated with i00 ml of water and 50 ml of concentrated sodium hydroxide solution. The solid was filtered off, and washed with a concentrated solution of potassium hydroxide (3• 20 ml ...