The synthesis and biological evaluation of a series of cup-bis [(dialkylamino) alkyl] phenylacetamides, 2, are presented. These compounds are structurally related to the antiarrhythmic agent disopyramide (1) and in many cases were found to possess greater antiarrhythmic activity in coronary ligated dogs. Within this series of compounds, a separation of the antiarrhythmic properties from the unwanted cardiac depressant side ...
![α-[(diisopropylamino)ethyl]-α-(1-piperidinoethyl)-o-chlorophenylacetonitrile Structure](https://image.chemsrc.com/caspic/186/68284-68-4.png)
