Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases

J Lee, SU Kang, SY Kim, SE Kim, YJ Jo…

Index: Lee, Jeewoo; Kang, Sang Uk; Kim, Su Yeon; Kim, Sung Eun; Jo, Yeong Joon; Kim, Sunghoon Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 8 p. 965 - 968

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Citation Number: 23

Abstract

As aminoacyl adenylate surrogates, a series of methionyl and isoleucyl phenolic analogues containing bioisosteric linkers mimicking ribose have been investigated. Inhibition of synthesized compounds to the aminoacylation reaction by the corresponding Escherichia coli methionyl-tRNA and isoleucyl-tRNA synthetases indicated that 18 was found to be a potent inhibitor of isoleucyl-tRNA synthetase. A molecular modeling study demonstrated ...