Medicinal chemistry research

Synthesis, anticonvulsant and toxicity screening of thiazolyl–thiadiazole derivatives

N Siddiqui, W Ahsan

Index: Siddiqui, Nadeem; Ahsan, Waquar Medicinal Chemistry Research, 2011 , vol. 20, # 2 p. 261 - 268

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Citation Number: 21

Abstract

Abstract Various thiazole-substituted thiadiazole derivatives (7a–t) were designed and synthesized using substituted acetophenones and substituted anilines as starting materials. Thiazole and thiadiazole moieties being anticonvulsants were clubbed together to get the titled compounds and their in vivo anticonvulsant screening were performed by two most adopted seizure models, maximal electroshock seizure (MES) and subcutaneous ...