Tetrahedron

Clean one-pot synthesis of 1, 2, 4-oxadiazoles under solvent-free conditions using microwave irradiation and potassium fluoride as catalyst and solid support

S Rostamizadeh, HR Ghaieni, R Aryan, AM Amani

Index: Rostamizadeh, Shahnaz; Ghaieni, Hamid Reza; Aryan, Reza; Amani, Ali Mohammad Tetrahedron, 2010 , vol. 66, # 2 p. 494 - 497

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Citation Number: 28

Abstract

Potassium fluoride was found to be an efficient catalyst and solid support for the synthesis of 3, 5-disubstituted-1, 2, 4-oxadiazoles. In this work, a one-pot method for the synthesis of these compounds from the reaction of nitriles with hydroxylamine hydrochloride and acyl chloride in the presence of potassium fluoride under solvent-free conditions using microwave irradiation has been developed. The advantages of using potassium fluoride ...