Compounds 7a {(f)-7-Chloro-8-hydroxy-3-[4-~ N, N-dimethylamino) butyl]-l-phenyl-2, 3, 4, 5- tetrahydro-lH-3-benzazepine), 11 {(f)-7-chloro-8-hydroxy-3-[6-[(N, N-dimethylamino) hexyl]- lphenyl-2, 3, 4, 5-tetrahydro-lH-3-benzazepine-cyanoborane}, and 15 were moderately potent dopamine D1 receptor antagonists as evidenced by their ability to block dopamine- stimulated adenylyl cyclase activity in rat caudate (predicted Ki values= 60, 34, and 21 nM, ...
[Minor, Deborah L.; Wyrick, Steven D.; Charifson, Paul S.; Watts, Val J.; Nichols, David E.; Mailman, Richard B. Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4317 - 4328]
