Regioselectivity in the Reformatskii reaction of 4-bromocrotonate. Role of the catalyst and the solvent in the normal vs. abnormal modes of addition to carbonyl …

…, BJ Suder, JO Frazier, T Hudlicky

Index: Rice, Leonard E.; Boston, M.Craig; Finklea, Harry O.; Suder, Billy Jo; Frazier, James O.; Hudlicky, Tomas Journal of Organic Chemistry, 1984 , vol. 49, # 10 p. 1845 - 1848

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Citation Number: 29

Abstract

Regioselectivity in the Reformatsky Reaction of 4-Bromocrotonate. Role of the Catalyst and the Solvent in the Normal vs. Abnormal Modes of Addition to Carbonyl Substratest ... Summary: The regioselectivity of addition of the orga- nozinc reagent derived from ethyl 4-bromocrotonate to 10 carbonyl substrates was found to be dependent on the polarity of solvents and the hardness of metal catalysts. ... Sir: The Reformatsky reaction constitutes a mild and versatile ...