Synthesis and antiproliferative activity of pyrrolo [3, 2-b] pyridine derivatives against melanoma

HJ Kim, MH Jung, H Kim, MI El-Gamal, TB Sim…

Index: Kim, Hee Jin; Jung, Myung-Ho; Kim, Hwan; El-Gamal, Mohammed I.; Sim, Tae Bo; Lee, So Ha; Hong, Jun Hee; Hah, Jung-Mi; Cho, Jung-Hyuck; Choi, Jung Hoon; Yoo, Kyung Ho; Oh, Chang-Hyun Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 413 - 417

Full Text: HTML

Citation Number: 27

Abstract

Synthesis of a new series of diarylureas and amides having pyrrolo [3, 2-b] pyridine scaffold is described. Their in vitro antiproliferative activity against human melanoma cell line A375 and HS 27 human fibroblast cell line was tested and the effect of substituents on the pyrrolo [3, 2-b] pyridine was investigated. The newly synthesized compounds, except meta- substituted derivatives (Ij–k and Iv–w), generally showed superior or similar activity ...