From Ynamides to Highly Substituted Benzo [b] furans: Gold (I)??Catalyzed 5??endo??dig??Cyclization/Rearrangement of Alkylic Oxonium Intermediates

…, V Weingand, F Rominger, ASK Hashmi

Index: Blanco Jaimes, Maria Camila; Weingand, Vanessa; Rominger, Frank; Hashmi, A. Stephen K. Chemistry - A European Journal, 2013 , vol. 19, # 37 p. 12504 - 12511

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Citation Number: 15

Abstract

Abstract A series of arylynamides with alkyloxy groups at the ortho position of the aryl group was prepared through a short alkylation/cross-coupling/amidation sequence. The gold- catalyzed conversion of these substrates combined both C [BOND] O and C [BOND] C formation steps, thus providing benzofurans with amine functionalities at the 2-position and alkyl groups at the 3-position. Cross-over experiments showed that the alkyl-migration ...