Chemical Communications

Enhanced reactivity and anti selectivity in the asymmetric Lewis acid-mediated Mukaiyama aldol reaction of α-alkoxythiolketene acetals with α, β-disubstituted enals: …

JD White, J Deerberg

Index: White; Deerberg Chemical Communications, 1997 , # 19 p. 1919 - 1920

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Abstract

The tin (II)-mediated reaction of α-alkoxythiolketene acetals 3a–d with trans-2-methylbut-2- enal and aldehyde 10 was found to give enhanced reactivity and high anti selectivity in the glycolate product when an α-benzyloxy substituent was present in 3, a finding which was