N-imidazolyl derivatives of the napththalene and chroman rings as thromboxane A 2 synthase inhibitors

P Cozzi, U Branzoli, G Carganico, C Ferti…

Index: Cozzi, P; Branzoli, U; Carganico, G; Ferti, C; Pillan, A; et al. European Journal of Medicinal Chemistry, 1991 , vol. 26, # 4 p. 423 - 433

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Citation Number: 9

Abstract

Abstract A series of N-imidazol-1-yl derivatives of 1, 2-dihydronaphthalene, 1, 2, 3, 4- tetrahydronaphthalene, 2H-1-benzopyran and some related compounds were synthesized and tested as inhibitors of thromboxane A 2 synthase in ex vivo experiments with orally treated rats. Some compounds showed good activity which was confirmed in experiments in vitro in rabbit whole blood. Some structural requirements for significant TxA 2 synthase ...