A Ligand??Library Approach to the Highly Efficient Rhodium/Phosphoramidite??Catalyzed Asymmetric Arylation of N, N??Dimethylsulfamoyl??Protected Aldimines

…, JG de Vries, BL Feringa, AJ Minnaard

Index: Jagt, Richard B. C.; Toullec, Patrick Y.; Geerdink, Danny; De Vries, Johannes G.; Feringa, Ben L.; Minnaard, Adriaan J. Angewandte Chemie - International Edition, 2006 , vol. 45, # 17 p. 2789 - 2791

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Citation Number: 141

Abstract

The asymmetric synthesis of diarylmethyl amines is of great importance because they are present in a variety of pharmacologically active structures.[1] Among other methods for performing the catalytic asymmetric synthesis of diarylmethyl amines,[2] the recently developed rhodium-catalyzed asymmetric arylation of aldimines is an important strategy.[3] Excellent enantioselectivities have been reported for the addition of aryl stannane [4] and ...