Thromboxane synthetase inhibitors (TXSI). Design, synthesis, and evaluation of a novel series of. omega.-pyridylalkenoic acids

K Kato, S Ohkawa, S Terao, Z Terashita…

Index: Kato, Kaneyoshi; Ohkawa, Shigenori; Terao, Shinji; Terashita, Zen-ichi; Nishikawa, Kohei Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 287 - 294

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Citation Number: 123

Abstract

A novel series of w-pyridylalkenoic acids has been prepared by applying the Wittig reaction. Modifications were made in the w-aryl moiety, the alkylene chain length, the a-methylene group adjacent to the carbonyl group, and the carboxyl group of the molecule. The compounds were tested as inhibitors of thromboxane synthetase in an in vitro assay and in ex vivo experiments with the rat. Most members of this new class of thromboxane ...