e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Tetrahedron

Chemistry of 6H-pyrido [4, 3-b] carbazoles part II: synthetic approaches to 6H-9-methoxy-5, 11-dimethylpyrido [4, 3-b] fluorenes

A Popplestone, M Sainsbury

Index: Popplestone Andrew; Sainsbury, Malcolm Tetrahedron, 1983 , vol. 39, # 24 p. 4103 - 4108

Full Text: HTML

Citation Number: 0

Abstract

Synthetic approaches to 6H-9-methoxy-5, 11-dimethylpyrido [4, 3-b] fluorene are described, thus 2-[1-(4-pyridyl) ethyl] 6-methoxyindanone has been reacted with vinylmagnesium bromide to yield 2-[1-(4-pyridyl) ethyl]-6 methoxy-1-vinyl-1-indanol. However, on dehydration this compound rearranges to 2-[1-(4-pyridyl) ethyl]-3-ethylidene-5- methoxyindene rather than the required isomer 3-ethylidine-2-[1-(4-pyridyl) ethyl]-5- ...

(3-bromo-4-methoxyphenyl)-(2,5-dimethylphenyl)methanone Structure

(3-bromo-4-meth...

~65%

2-bromo-4-[(2,5-dimethylphenyl)methyl]phenol Structure

2-bromo-4-[(2,5...

(2,5-dimethylphenyl)-(4-methoxyphenyl)methanone Structure

(2,5-dimethylph...

~%

2-bromo-4-[(2,5-dimethylphenyl)methyl]phenol Structure

2-bromo-4-[(2,5...

2,5-Dimethylbenzoic acid Structure

2,5-Dimethylben...

~%

2-bromo-4-[(2,5-dimethylphenyl)methyl]phenol Structure

2-bromo-4-[(2,5...

bromoanisole Structure

~%

2-bromo-4-[(2,5-dimethylphenyl)methyl]phenol Structure

2-bromo-4-[(2,5...

2-bromo-4-[(2,5-dimethylphenyl)methyl]phenol Structure

2-bromo-4-[(2,5...

methyl iodide Structure

~85%

2-bromo-4-[(2,5-dimethylphenyl)methyl]-1-methoxybenzene Structure

2-bromo-4-[(2,5...

bromoanisole Structure

~%

2-bromo-4-[(2,5-dimethylphenyl)methyl]-1-methoxybenzene Structure

2-bromo-4-[(2,5...

(3-bromo-4-methoxyphenyl)-(2,5-dimethylphenyl)methanone Structure

(3-bromo-4-meth...

~%

2-bromo-4-[(2,5-dimethylphenyl)methyl]-1-methoxybenzene Structure

2-bromo-4-[(2,5...

(2,5-dimethylphenyl)-(4-methoxyphenyl)methanone Structure

(2,5-dimethylph...

~%

2-bromo-4-[(2,5-dimethylphenyl)methyl]-1-methoxybenzene Structure

2-bromo-4-[(2,5...

2,5-Dimethylbenzoic acid Structure

2,5-Dimethylben...

~%

2-bromo-4-[(2,5-dimethylphenyl)methyl]-1-methoxybenzene Structure

2-bromo-4-[(2,5...

m-Bromoanisole Structure

~%

6-methoxy-1,4-dimethylfluoren-9-one Structure

6-methoxy-1,4-d...

2,5-Dimethylbenzoic acid Structure

2,5-Dimethylben...

~%

6-methoxy-1,4-dimethylfluoren-9-one Structure

6-methoxy-1,4-d...

(2-bromo-4-methoxyphenyl)-(2,5-dimethylphenyl)methanone Structure

(2-bromo-4-meth...

~12%

6-methoxy-1,4-dimethylfluoren-9-one Structure

6-methoxy-1,4-d...

6-methoxy-2-[1-methyl-1-(4-pyridyl)methylene]indanone Structure

6-methoxy-2-[1-...

~%

4-[1-(1-ethylidene-6-methoxyinden-2-yl)ethyl]pyridine Structure

4-[1-(1-ethylid...

6-methoxy-2-(1-(4-pyridyl)ethyl)-1-vinyl-1-indanol Structure

6-methoxy-2-(1-...

~10%

4-[1-(1-ethylidene-6-methoxyinden-2-yl)ethyl]pyridine Structure

4-[1-(1-ethylid...

6-methoxy-2-(1-(4-pyridyl)ethyl)indanon Structure

6-methoxy-2-(1-...

~%

4-[1-(1-ethylidene-6-methoxyinden-2-yl)ethyl]pyridine Structure

4-[1-(1-ethylid...

(2,5-dimethylphenyl)-(4-methoxyphenyl)methanone Structure

(2,5-dimethylph...

~62%

(3-bromo-4-methoxyphenyl)-(2,5-dimethylphenyl)methanone Structure

(3-bromo-4-meth...

bromoanisole Structure

2,5-Dimethylbenzoic acid Structure

2,5-Dimethylben...

~59%

(3-bromo-4-methoxyphenyl)-(2,5-dimethylphenyl)methanone Structure

(3-bromo-4-meth...