Abstract Various tetrahydrofuran-2-ylmethylamines have been prepared in good yields by an efficient one-step synthesis utilizing the reaction of tetrahydrofurfurylchloride with different secondary cyclic amines without any catalyst. The compounds were tested for their in vitro affinity for the (α4) 2 (β2) 3 and α7* nicotinic acetylcholine receptor (nAChR) subtypes. Pyrrolidine, piperidine and azepane containing analogs (1a, 1b, 1c) showed K i values in ...
